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Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) 是一种有效的、可口服的、具有抗肿瘤活性的选择性 ATR 抑制剂。
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) 是一种有效的、可口服的、具有抗肿瘤活性的选择性 ATR 抑制剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 287 | 现货 | |
5 mg | ¥ 792 | 现货 | |
10 mg | ¥ 1,190 | 现货 | |
25 mg | ¥ 2,390 | 现货 | |
50 mg | ¥ 3,400 | 现货 | |
100 mg | ¥ 4,750 | 现货 | |
200 mg | ¥ 6,390 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 852 | 现货 |
产品描述 | Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity. |
靶点活性 | ATR:7 nM |
体外活性 | Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1]. |
体内活性 | In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2]. |
别名 | BAY-1895344 hydrochloride |
分子量 | 411.89 |
分子式 | C20H22ClN7O |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (121.39 mM), Sonication and heating are recommended. H2O: 48 mg/mL (116.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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